On Going Clinical Trials

1. BMX - 010 Preservation of Islet Cell Mass and Function for Clinical Islet Transplantation [click here for study description]

2. Improving Single Donor Success Rate in Clinical Islet Transplantation using Alpha-1 Antitrypsin (Aralast NP) [click here for study description]

3. Assessing the Safety and Efficacy of the Gastric Submucosal Space in Clinical Islet Transplantation [click here for study description]

4. A Safety, Tolerability, and Efficacy Study of VC-01™ Combination Product in Subjects With Type I Diabetes Mellitus [click here for study description]

5. Stem Cell Mobilization (Plerixafor) and Immunologic Reset in New Onset Type 1 Diabetes Mellitus [click here for study description]


If you wish to register your interest to volunteer for one of our current or future research studies, please click here.



Moore SJ, Gala-Lopez BL, Pepper AR, Pawlick RL, Shapiro AJ. Bioengineered stem cells as an alternative for islet cell transplantation. World J Transplant. 2015 Mar 24;5(1):1-10. doi: 10.5500/wjt.v5.i1.1. Review. PubMed PMID: 25815266; PubMed Central PMCID: PMC4371156.

Pepper AR, Gala-Lopez B, Pawlick R, Merani S, Kin T, Shapiro AM. A prevascularized subcutaneous device-less site for islet and cellular transplantation. Nat Biotechnol. 2015 Apr 20. doi: 10.1038/nbt.3211. [Epub ahead of print] PubMed PMID: 25893782.

Senior PA, Bellin MD, Alejandro R, Yankey JW, Clarke WR, Qidwai JC, Schwieger TR, Eggerman TL, Robien MA, Rickels MR. Consistency of quantitative scores of hypoglycemia severity and glycemic lability and comparison with continuous glucose monitoring system measures in long-standing type 1 diabetes. Diabetes Technol Ther. 2015 Apr;17(4):235-42. doi: 10.1089/dia.2014.0289. Epub 2015 Jan 28. PubMed PMID: 25629445.


Balamurugan AN, Naziruddin B, Lockridge A, Tiwari M, Loganathan G, Takita M, Matsumoto S, Papas K, Trieger M, Rainis H, Kin T, Kay TW, Wease S, Messinger S, Ricordi C, Alejandro R, Markmann J, Kerr-Conti J, Rickels MR, Liu C, Zhang X, Witkowski P, Posselt A, Maffi P, Secchi A, Berney T, O'Connell PJ, Hering BJ, Barton FB. Islet product characteristics and factors related to successful human islet transplantation from the Collaborative Islet Transplant Registry (CITR) 1999-2010. Am J Transplant. 2014 Nov;14(11):2595-606. doi: 10.1111/ajt.12872. Epub 2014 Oct 2. PubMed PMID: 25278159; PubMed Central PMCID: PMC4282081.

Pawlick R, Gala-Lopez B, Pepper AR, McCall M, Ziff O, Shapiro AM. The combination of anti-NKG2D and CTLA-4 Ig therapy prolongs islet allograft survival in a murine model. Am J Transplant. 2014 Oct;14(10):2367-74. doi: 10.1111/ajt.12838. Epub 2014 Sep 1. Erratum in: Am J Transplant. 2014 Nov;14(11):2674. PubMed PMID: 25179027.

Kitzmann JP, Pepper AR, Gala-Lopez B, Pawlick R, Kin T, O'Gorman D, Mueller KR, Gruessner AC, Avgoustiniatos ES, Karatzas T, Szot GL, Posselt AM, Stock PG, Wilson JR, Shapiro AM, Papas KK. Human islet viability and function is maintained during high-density shipment in silicone rubber membrane vessels. Transplant Proc. 2014 Jul-Aug;46(6):1989-91. doi: 10.1016/j.transproceed.2014.06.002. PubMed PMID: 25131090; PubMed Central PMCID: PMC4169700.

Kitzmann JP, O'Gorman D, Kin T, Gruessner AC, Senior P, Imes S, Gruessner RW, Shapiro AM, Papas KK. Islet oxygen consumption rate dose predicts insulin independence for first clinical islet allotransplants. Transplant Proc. 2014 Jul-Aug;46(6):1985-8. doi: 10.1016/j.transproceed.2014.06.001. PubMed PMID: 25131089; PubMed Central PMCID: PMC4170186.

Bruni A, Gala-Lopez B, Pepper AR, Abualhassan NS, Shapiro AJ. Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges. Diabetes Metab Syndr Obes. 2014 Jun 23;7:211-23. doi: 10.2147/DMSO.S50789. eCollection 2014. Review. PubMed PMID: 25018643; PubMed Central PMCID: PMC4075233.

Andres A, Kin T, O'Gorman D, Bigam D, Kneteman N, Senior P, Shapiro AJ. Impact of adverse pancreatic injury at surgical procurement upon islet isolation outcome. Transpl Int. 2014 Nov;27(11):1135-42. doi: 10.1111/tri.12392. Epub 2014 Aug 24. PubMed PMID: 24977306.

McCall M, Shapiro AM. Islet cell transplantation. Semin Pediatr Surg. 2014 Apr;23(2):83-90. doi: 10.1053/j.sempedsurg.2014.03.006. Epub 2014 May 2. PubMed PMID: 24931353.

Al-Adra DP, Gill RS, Imes S, O'Gorman D, Kin T, Axford SJ, Shi X, Senior PA, Shapiro AM. Single-donor islet transplantation and long-term insulin independence in select patients with type 1 diabetes mellitus. Transplantation. 2014 Nov 15;98(9):1007-12. doi: 10.1097/TP.0000000000000217. PubMed PMID: 4911037.


Canadian Diabetes Association Clinical Practice Guidelines Expert Committee, Paty BW, Koh A, Senior P. Pancreas and islet transplantation. Can J Diabetes. 2013 Apr;37 Suppl 1:S94-6. doi: 10.1016/j.jcjd.2013.01.028. Epub 2013 Mar 26. PubMed PMID: 24070973.

Miranda PM, Mohan V, Ganthimathy S, Anjana RM, Gunasekaran S, Thiagarajan V, Churchill TA, Kin T, Shapiro AM, Lakey JR. Human islet mass, morphology, and survival after cryopreservation using the Edmonton protocol. Islets. 2013 Sep-Dec;5(5):188-95. doi: 10.4161/isl.26304. PubMed PMID: 24759005; PubMed Central PMCID: PMC4010570.

Pepper AR, Gala-Lopez B, Ziff O, Shapiro AJ. Current status of clinical islet transplantation. World J Transplant. 2013 Dec 24;3(4):48-53. doi: 10.5500/wjt.v3.i4.48. PubMed PMID: 24392308; PubMed Central PMCID: PMC3879523.

Pepper AR, Gala-Lopez B, Ziff O, Shapiro AM. Revascularization of transplanted pancreatic islets and role of the transplantation site. Clin Dev Immunol. 2013;2013:352315. doi: 10.1155/2013/352315. Epub 2013 Sep 9. Review. PubMed PMID: 24106517; PubMed Central PMCID: PMC3782812.

Gala-Lopez B, Pepper AR, Shapiro AM. Biologic agents in islet transplantation. Curr Diab Rep. 2013 Oct;13(5):713-22. doi: 10.1007/s11892-013-0414-8. Review. PubMed PMID: 23918618.

O'Gorman D, Kin T, Pawlick R, Imes S, Senior PA, Shapiro AM. Clinical islet isolation outcomes with a highly purified neutral protease for pancreas dissociation. Islets. 2013 May-Jun;5(3):111-5. doi: 10.4161/isl.25222. Epub 2013 Jun 11. PubMed PMID: 23756701; PubMed Central PMCID: PMC4049837.

Koh A, Imes S, Shapiro AM, Senior PA. Successful treatment of brittle diabetes following total pancreatectomy by islet allotransplantation: a case report. JOP. 2013 Jul 10;14(4):428-31. doi: 10.6092/1590-8577/1440. PubMed PMID: 23846941.

 Shapiro AM. Immune antibody monitoring predicts outcome in islet transplantation. Diabetes. 2013 May;62(5):1377-8. doi: 10.2337/db13-0019. PubMed PMID: 23613556; PubMed Central PMCID: PMC3636639.

Jackson S, Mager DR, Bhargava R, Ackerman T, Imes S, Hubert G, Koh A, Shapiro AM, Senior PA. Long-term follow-up of hepatic ultrasound findings in subjects with magnetic resonance imaging defined hepatic steatosis following clinical islet transplantation: a case-control study. Islets. 2013 Jan-Feb;5(1):16-21. doi: 10.4161/isl.24058. Epub 2013 Jan 1. PubMed PMID: 23514958; PubMed Central PMCID: PMC3662378.

 Gala-Lopez B, Kin T, O'Gorman D, Pepper AR, Senior P, Humar A, Shapiro AM.

Microbial contamination of clinical islet transplant preparations is associated

with very low risk of infection. Diabetes Technol Ther. 2013 Apr;15(4):323-7.

doi: 10.1089/dia.2012.0297. Epub 2013 Feb 25. PubMed PMID: 23438305; PubMed

Central PMCID: PMC3661032.

22: do Amaral AS, Pawlick RL, Rodrigues E, Costal F, Pepper A, Galvão FH,

Correa-Giannella ML, Shapiro AM. Glutathione ethyl ester supplementation during

pancreatic islet isolation improves viability and transplant outcomes in a murine

marginal islet mass model. PLoS One. 2013;8(2):e55288. doi:

10.1371/journal.pone.0055288. Epub 2013 Feb 12. PubMed PMID: 23424628; PubMed

Central PMCID: PMC3570543.


23: Silva M, Humar A, Shapiro AM, Senior P, Hoschler K, Baluch A, Wilson LE,

Kumar D. Humoral immune response following seasonal influenza vaccine in islet

transplant recipients. Cell Transplant. 2013;22(3):469-76. doi:

10.3727/096368912X656135. Epub 2012 Sep 21. PubMed PMID: 23006439.

24: Al-Adra DP, Pawlick R, Shapiro AM, Anderson CC. Targeting cells causing split

tolerance allows fully allogeneic islet survival with minimal conditioning in NOD

mixed chimeras. Am J Transplant. 2012 Dec;12(12):3235-45. doi:

10.1111/j.1600-6143.2012.04260.x. Epub 2012 Sep 13. PubMed PMID: 22974315.

25: McCall M, Shapiro AM. Update on islet transplantation. Cold Spring Harb

Perspect Med. 2012 Jul;2(7):a007823. doi: 10.1101/cshperspect.a007823. Review.

PubMed PMID: 22762022; PubMed Central PMCID: PMC3385934.

26: Barton FB, Rickels MR, Alejandro R, Hering BJ, Wease S, Naziruddin B,

Oberholzer J, Odorico JS, Garfinkel MR, Levy M, Pattou F, Berney T, Secchi A,

Messinger S, Senior PA, Maffi P, Posselt A, Stock PG, Kaufman DB, Luo X, Kandeel 

F, Cagliero E, Turgeon NA, Witkowski P, Naji A, O'Connell PJ, Greenbaum C, Kudva 

YC, Brayman KL, Aull MJ, Larsen C, Kay TW, Fernandez LA, Vantyghem MC, Bellin M, 

Shapiro AM. Improvement in outcomes of clinical islet transplantation: 1999-2010.

Diabetes Care. 2012 Jul;35(7):1436-45. doi: 10.2337/dc12-0063. PubMed PMID:

22723582; PubMed Central PMCID: PMC3379615.

27: McCall MD, Maciver AM, Kin T, Emamaullee J, Pawlick R, Edgar R, Shapiro AM.

Caspase inhibitor IDN6556 facilitates marginal mass islet engraftment in a

porcine islet autotransplant model. Transplantation. 2012 Jul 15;94(1):30-5. doi:

10.1097/TP.0b013e318257745d. PubMed PMID: 22706322.

28: Yeung TY, Seeberger KL, Kin T, Adesida A, Jomha N, Shapiro AM, Korbutt GS.

Human mesenchymal stem cells protect human islets from pro-inflammatory

cytokines. PLoS One. 2012;7(5):e38189. doi: 10.1371/journal.pone.0038189. Epub

2012 May 30. PubMed PMID: 22666480; PubMed Central PMCID: PMC3364233.

29: Merani S, Famulski KS, Ramassar V, Shapiro AJ, Halloran PF. Characterization 

of the transcriptome in isolated and transplanted mouse pancreatic islets:

associations with engraftment and dysfunction. Islets. 2012 Mar-Apr;4(2):158-66. 

doi: 10.4161/isl.19770. Epub 2012 Mar 1. PubMed PMID: 22653155.

30: Shapiro AM. Islet transplantation in type 1 diabetes: ongoing challenges,

refined procedures, and long-term outcome. Rev Diabet Stud. 2012

Winter;9(4):385-406. doi: 10.1900/RDS.2012.9.385. Epub 2012 Dec 28. Review.

PubMed PMID: 23804275; PubMed Central PMCID: PMC3740705.

31: Kin T, O'Gorman D, Schroeder A, Onderka C, Richer B, Rosichuk S, Zhai X,

Shapiro AM. Human islet distribution program for basic research at a single

center. Transplant Proc. 2011 Nov;43(9):3195-7. doi:

10.1016/j.transproceed.2011.10.003. PubMed PMID: 22099755.

32: Shapiro AM. Strategies toward single-donor islets of Langerhans

transplantation. Curr Opin Organ Transplant. 2011 Dec;16(6):627-31. doi:

10.1097/MOT.0b013e32834cfb84. Review. PubMed PMID: 22068022; PubMed Central

PMCID: PMC3268080.

33: McCall M, Pawlick R, Kin T, Shapiro AM. Anakinra potentiates the protective

effects of etanercept in transplantation of marginal mass human islets in

immunodeficient mice. Am J Transplant. 2012 Feb;12(2):322-9. doi:

10.1111/j.1600-6143.2011.03796.x. Epub 2011 Nov 4. PubMed PMID: 22053751.


34: Senior PA, Koh A, Shapiro AM. Remission of alopecia universalis following

successful clinical islet transplantation. Am J Transplant. 2011

Nov;11(11):2536-7. doi: 10.1111/j.1600-6143.2011.03758.x. Epub 2011 Sep 22.

PubMed PMID: 21951462.

35: Merani S, McCall M, Pawlick RL, Edgar RL, Davis J, Toso C, Emamaullee JA, Kin

T, Shapiro AM. AEB071 (sotrastaurin) does not exhibit toxic effects on human

islets in vitro, nor after transplantation into immunodeficient mice. Islets.

2011 Nov-Dec;3(6):338-43. doi: 10.4161/isl.3.6.17766. Epub 2011 Nov 1. PubMed

PMID: 21934354.

36: Gala-Lopez BL, Senior PA, Koh A, Kashkoush SM, Kawahara T, Kin T, Humar A,

Shapiro AM. Late cytomegalovirus transmission and impact of T-depletion in

clinical islet transplantation. Am J Transplant. 2011 Dec;11(12):2708-14. doi:

10.1111/j.1600-6143.2011.03724.x. Epub 2011 Sep 11. PubMed PMID: 21906252.

37: McCall MD, Pawlick R, Shapiro AM. Resveratrol fails to improve marginal mass 

engraftment of transplanted islets of Langerhans in mice. Islets. 2011

Sep-Oct;3(5):241-5. doi: 10.4161/isl.3.5.16698. PubMed PMID: 21904116.

38: Kawahara T, Kin T, Kashkoush S, Gala-Lopez B, Bigam DL, Kneteman NM, Koh A,

Senior PA, Shapiro AM. Portal vein thrombosis is a potentially preventable

complication in clinical islet transplantation. Am J Transplant. 2011

Dec;11(12):2700-7. doi: 10.1111/j.1600-6143.2011.03717.x. Epub 2011 Aug 29.

PubMed PMID: 21883914; PubMed Central PMCID: PMC3226916.

39: Kawahara T, Kin T, Shapiro AM. A comparison of islet autotransplantation with

allotransplantation and factors elevating acute portal pressure in clinical islet

transplantation. J Hepatobiliary Pancreat Sci. 2012 May;19(3):281-8. doi:

10.1007/s00534-011-0441-2. PubMed PMID: 21879320.

40: Shapiro AM. State of the art of clinical islet transplantation and novel

protocols of immunosuppression. Curr Diab Rep. 2011 Oct;11(5):345-54. doi:

10.1007/s11892-011-0217-8. Review. PubMed PMID: 21830042.

41: McCall MD, Pawlick R, Shapiro AM. Resveratrol fails to improve marginal mass 

engraftment of transplanted islets of Langerhans in mice. Islets. 2011 Sep

1;3(5). [Epub ahead of print] PubMed PMID: 21757994.

42: ElSaadany S, Tyshenko MG, Oraby T, Malcolm AJ, Senior P, Shapiro AM, Catford 

A, Salem T, Wu J, Krewski D, Rohwer RG. The risk to human islet cell transplant

recipients of acquiring variant Creutzfeldt-Jakob disease: a provisional

quantitative risk assessment. Transplantation. 2011 Jul 15;92(1):e2-4. doi:

10.1097/TP.0b013e31821eabab. PubMed PMID: 21691192.

43: McCall M, Toso C, Emamaullee J, Pawlick R, Edgar R, Davis J, Maciver A, Kin

T, Arch R, Shapiro AM. The caspase inhibitor IDN-6556 (PF3491390) improves

marginal mass engraftment after islet transplantation in mice. Surgery. 2011

Jul;150(1):48-55. doi: 10.1016/j.surg.2011.02.023. Epub 2011 May 18. PubMed PMID:


44: Zuk DM, Koh A, Imes S, Shapiro AM, Senior PA. Three cases of alopecia

following clinical islet transplantation. Am J Transplant. 2011 Jan;11(1):163-8. 

doi: 10.1111/j.1600-6143.2010.03348.x. PubMed PMID: 21199356; PubMed Central

PMCID: PMC3052626.


45: Kin T, O'Gorman D, Senior P, Shapiro AM. Experience of islet isolation

without neutral protease supplementation. Islets. 2010 Sep-Oct;2(5):278-82. Epub 

2010 Sep 1. PubMed PMID: 21099325; PubMed Central PMCID: PMC3230559.

46: Kin T, Shapiro AM. Surgical aspects of human islet isolation. Islets. 2010

Sep-Oct;2(5):265-73. Epub 2010 Sep 1. Review. PubMed PMID: 21099323; PubMed

Central PMCID: PMC3230558.

47: Kin T, Shapiro J. Partial dorsal agenesis accompanied with circumportal

pancreas in a donor for islet transplantation. Islets. 2010 May-Jun;2(3):146-8.

doi: 10.4161/isl.2.3.11715. PubMed PMID: 21099308.

48: Lacotte S, Berney T, Shapiro AJ, Toso C. Immune monitoring of pancreatic

islet graft: towards a better understanding, detection and treatment of harmful

events. Expert Opin Biol Ther. 2011 Jan;11(1):55-66. doi:

10.1517/14712598.2011.536530. Epub 2010 Nov 12. Review. PubMed PMID: 21073277.

49: Toso C, Pawlick R, Lacotte S, Edgar R, Davis J, McCall M, Morel P, Mentha G, 

Berney T, Shapiro AM. Detecting rejection after mouse Islet transplantation

utilizing islet protein-stimulated ELISPOT. Cell Transplant. 2011;20(6):955-62.

doi: 10.3727/096368910X539137. Epub 2010 Nov 5. PubMed PMID: 21054945.

50: O'Gorman D, Kin T, Imes S, Pawlick R, Senior P, Shapiro AM. Comparison of

human islet isolation outcomes using a new mammalian tissue-free enzyme versus

collagenase NB-1. Transplantation. 2010 Aug 15;90(3):255-9. doi:

10.1097/TP.0b013e3181e117ce. PubMed PMID: 20463640.

51: Emamaullee JA, Davis J, Pawlick R, Toso C, Merani S, Cai SX, Tseng B, Shapiro

AM. Caspase inhibitor therapy synergizes with costimulation blockade to promote

indefinite islet allograft survival. Diabetes. 2010 Jun;59(6):1469-77. doi:

10.2337/db09-0502. Epub 2010 Mar 23. PubMed PMID: 20332344; PubMed Central PMCID:


52: Low G, Hussein N, Owen RJ, Toso C, Patel VH, Bhargava R, Shapiro AM. Role of 

imaging in clinical islet transplantation. Radiographics. 2010 Mar;30(2):353-66. 

doi: 10.1148/rg.302095741. Review. Erratum in: Radiographics. 2010

May-Jun;30(3):844. PubMed PMID: 20228322.

53: Kin T. Islet isolation for clinical transplantation. Adv Exp Med Biol.

2010;654:683-710. doi: 10.1007/978-90-481-3271-3_30. Review. PubMed PMID:


54: Toso C, Merani S, Bigam DL, Shapiro AM, Kneteman NM. Sirolimus-based

immunosuppression is associated with increased survival after liver

transplantation for hepatocellular carcinoma. Hepatology. 2010 Apr;51(4):1237-43.

doi: 10.1002/hep.23437. PubMed PMID: 20187107.

55: Koh A, Senior P, Salam A, Kin T, Imes S, Dinyari P, Malcolm A, Toso C,

Nilsson B, Korsgren O, Shapiro AM. Insulin-heparin infusions peritransplant

substantially improve single-donor clinical islet transplant success.

Transplantation. 2010 Feb 27;89(4):465-71. doi: 10.1097/TP.0b013e3181c478fd.

PubMed PMID: 20177350.

56: Koh A, Imes S, Kin T, Dinyari P, Malcolm A, Toso C, Shapiro AM, Senior P.

Supplemental islet infusions restore insulin independence after graft dysfunction

in islet transplant recipients. Transplantation. 2010 Feb 15;89(3):361-5. doi:

10.1097/TP.0b013e3181bcdbe8. PubMed PMID: 20145529.


57: Toso C, Isse K, Demetris AJ, Dinyari P, Koh A, Imes S, Kin T, Emamaullee J,

Senior P, Shapiro AM. Histologic graft assessment after clinical islet

transplantation. Transplantation. 2009 Dec 15;88(11):1286-93. doi:

10.1097/TP.0b013e3181bc06b0. PubMed PMID: 19996928.

58: Toso C, McCall M, Emamaullee J, Merani S, Davis J, Edgar R, Pawlick R, Kin T,

Knudsen LB, Shapiro AM. Liraglutide, a long-acting human glucagon-like peptide 1 

analogue, improves human islet survival in culture. Transpl Int. 2010 Mar

1;23(3):259-65. doi: 10.1111/j.1432-2277.2009.00984.x. Epub 2009 Oct 12. PubMed

PMID: 19821955.

59: McCall MD, Toso C, Baetge EE, Shapiro AM. Are stem cells a cure for diabetes?

Clin Sci (Lond). 2009 Oct 12;118(2):87-97. doi: 10.1042/CS20090072. Review.

PubMed PMID: 19807695.

60: CITR Research Group. 2007 update on allogeneic islet transplantation from the

Collaborative Islet Transplant Registry (CITR). Cell Transplant.

2009;18(7):753-67. doi: 10.3727/096368909X470874. Epub 2009 Sep 28. PubMed PMID: 


61: Kin T, Shapiro AM. Circumportal pancreas and islet isolation. Surgery. 2009

Jul;146(1):126-7. doi: 10.1016/j.surg.2008.04.017. Epub 2008 Aug 10. PubMed PMID:


62: Kin T, O'Gorman D, Zhai X, Pawlick R, Imes S, Senior P, Shapiro AM.

Nonsimultaneous administration of pancreas dissociation enzymes during islet

isolation. Transplantation. 2009 Jun 15;87(11):1700-5. doi:

10.1097/TP.0b013e3181a60240. PubMed PMID: 19502963.

63: Emamaullee J, Toso C, Merani S, Shapiro AM. Costimulatory blockade with

belatacept in clinical and experimental transplantation - a review. Expert Opin

Biol Ther. 2009 Jun;9(6):789-96. doi: 10.1517/14712590902942284 . Review. PubMed 

PMID: 19426116.

64: Truong W, Hancock WW, Plester JC, Merani S, Rayner DC, Thangavelu G, Murphy

KM, Anderson CC, Shapiro AM. BTLA targeting modulates lymphocyte phenotype,

function, and numbers and attenuates disease in nonobese diabetic mice. J Leukoc 

Biol. 2009 Jul;86(1):41-51. doi: 10.1189/jlb.1107753. Epub 2009 Apr 21. PubMed

PMID: 19383625.

65: Owen RJ, Mercer JR, Al-Saif F, Molinari M, Ashforth RA, Rajotte RV,

Conner-Spady B, Shapiro AM. Portal vein embolization with radiolabeled polyvinyl 

alcohol particles in a swine model: hepatic distribution and implications for

pancreatic islet cell transplantation. Cardiovasc Intervent Radiol. 2009

May;32(3):499-507. doi: 10.1007/s00270-009-9544-4. Epub 2009 Mar 28. PubMed PMID:


66: Merani S, Edgar RL, Toso C, Emamaullee J, Thiesen A, Shapiro AM. AEB-071 has 

minimal impact on onset of autoimmune diabetes in NOD mice. Autoimmunity. 2009

Mar;42(3):242-8. doi: 10.1080/08916930802587950. PubMed PMID: 19301207.

67: Emamaullee JA, Davis J, Merani S, Toso C, Elliott JF, Thiesen A, Shapiro AM. 

Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice. Diabetes.

2009 Jun;58(6):1302-11. doi: 10.2337/db08-1113. Epub 2009 Mar 16. PubMed PMID:

19289457; PubMed Central PMCID: PMC2682686.

Alfadhli E, Koh A, Albaker W, Bhargava R, Ackerman T, McDonald C, Ryan EA, Shapiro AM, Senior PA. High prevalence of ovarian cysts in premenopausal women receiving sirolimus and tacrolimus after clinical islet transplantation. Transpl Int. 2009 Jun;22(6):622-5. doi: 10.1111/j.1432-2277.2009.00839.x. Epub 2009 Feb 2. PubMed PMID: 19207188.

Merani S, Pawlick RL, Edgar RL, Toso C, Emamaullee J, Anderson CC, Shapiro AM. Protein kinase C inhibitor, AEB-071, acts complementarily with cyclosporine to prevent islet rejection in rats. Transplantation. 2009 Jan 15;87(1):59-65. doi: 10.1097/TP.0b013e31819198b4. PubMed PMID: 19136892.


Kin T, O'Neil JJ, Pawlick R, Korbutt GS, Shapiro AM, Lakey JR. The use of an 

approved biodegradable polymer scaffold as a solid support system for improvement

of islet engraftment. Artif Organs. 2008 Dec;32(12):990-3. doi:

10.1111/j.1525-1594.2008.00688.x. PubMed PMID: 19133030.

Emamaullee JA, Merani S, Toso C, Kin T, Al-Saif F, Truong W, Pawlick R, Davis

J, Edgar R, Lock J, Bonner-Weir S, Knudsen LB, Shapiro AM. Porcine marginal mass 

islet autografts resist metabolic failure over time and are enhanced by early

treatment with liraglutide. Endocrinology. 2009 May;150(5):2145-52. doi:

10.1210/en.2008-1116. Epub 2009 Jan 8. PubMed PMID: 19131571.

72: Alejandro R, Barton FB, Hering BJ, Wease S; Collaborative Islet Transplant

Registry Investigators. 2008 Update from the Collaborative Islet Transplant

Registry. Transplantation. 2008 Dec 27;86(12):1783-8. doi:

10.1097/TP.0b013e3181913f6a. PubMed PMID: 19104422.

73: Koh A, Kin T, Imes S, Shapiro AM, Senior P. Islets isolated from donors with 

elevated HbA1c can be successfully transplanted. Transplantation. 2008 Dec

15;86(11):1622-4. doi: 10.1097/TP.0b013e31818c2559. PubMed PMID: 19077899.

74: Merani S, Toso C, Emamaullee J, Shapiro AM. Optimal implantation site for

pancreatic islet transplantation. Br J Surg. 2008 Dec;95(12):1449-61. doi:

10.1002/bjs.6391. Review. PubMed PMID: 18991254.

75: Fiorina P, Shapiro AM, Ricordi C, Secchi A. The clinical impact of islet

transplantation. Am J Transplant. 2008 Oct;8(10):1990-7. doi:

10.1111/j.1600-6143.2008.02353.x. Review. PubMed PMID: 18828765.

76: Shapiro AM. Islet transplantation--the imperative need for continued clinical

trials. Nat Clin Pract Nephrol. 2008 Dec;4(12):662-3. doi: 10.1038/ncpneph0964.

Epub 2008 Sep 30. PubMed PMID: 18825154.

77: Toso C, Edgar R, Pawlick R, Emamaullee J, Merani S, Dinyari P, Mueller TF,

Shapiro AM, Anderson CC. Effect of different induction strategies on effector,

regulatory and memory lymphocyte sub-populations in clinical islet

transplantation. Transpl Int. 2009 Feb;22(2):182-91. doi:

10.1111/j.1432-2277.2008.00746.x. Epub 2008 Aug 15. PubMed PMID: 18713144.

78: Kin T, Zhai X, O'Gorman D, Shapiro AM. Detrimental effect of excessive

collagenase class II on human islet isolation outcome. Transpl Int. 2008

Nov;21(11):1059-65. doi: 10.1111/j.1432-2277.2008.00734.x. Epub 2008 Aug 1.

PubMed PMID: 18680482.

79: Ricordi C, Hering BJ, Shapiro AM; Clinical Islet Transplantation Consortium. 

Beta-cell transplantation for diabetes therapy. Lancet. 2008 Jul

5;372(9632):27-8; author reply 29-30. doi: 10.1016/S0140-6736(08)60984-8. PubMed 

PMID: 18603151.

80: Kin T, Senior P, O'Gorman D, Richer B, Salam A, Shapiro AM. Risk factors for 

islet loss during culture prior to transplantation. Transpl Int. 2008

Nov;21(11):1029-35. doi: 10.1111/j.1432-2277.2008.00719.x. Epub 2008 Jun 18.

PubMed PMID: 18564983.

81: Merani S, Truong W, Emamaullee JA, Toso C, Knudsen LB, Shapiro AM.

Liraglutide, a long-acting human glucagon-like peptide 1 analog, improves glucose

homeostasis in marginal mass islet transplantation in mice. Endocrinology. 2008

Sep;149(9):4322-8. doi: 10.1210/en.2008-0501. Epub 2008 May 29. PubMed PMID:


82: Emamaullee JA, Merani S, Larsen CP, Shapiro AM. Belatacept and basiliximab

diminish human antiporcine xenoreactivity and synergize to inhibit alloimmunity. 

Transplantation. 2008 Jan 15;85(1):118-24. doi:

10.1097/01.tp.0000296832.92128.94. PubMed PMID: 18192921.

 Truong W, Plester JC, Hancock WW, Kaye J, Merani S, Murphy KM, Murphy TL, Anderson CC, Shapiro AM. Negative and positive co-signaling with anti-BTLA (PJ196) and CTLA4Ig prolongs islet allograft survival. Transplantation. 2007 Nov 27;84(10):1368-72. Erratum in: Transplantation. 2008 Jun 27;85(12):1872-3. PubMed PMID: 18049125.

Truong W, Plester JC, Hancock WW, Merani S, Murphy TL, Murphy KM, Kaye J, Anderson CC, Shapiro AM. Combined coinhibitory and costimulatory modulation with anti-BTLA and CTLA4Ig facilitates tolerance in murine islet allografts. Am J Transplant. 2007 Dec;7(12):2663-74. Erratum in: Am J Transplant. 2008 Feb;8(2):471. PubMed PMID: 17983390.

  1. Emamaullee JA, Davis J, Pawlick R, Merani S, Cai S, Tseng B, Shapiro AMJ. The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice. Published ahead of print, Diabetes, March 20, 2008.


  1. Shapiro AMJ, Bowker S, Dinyari P, Paty B, Ryan EA, Senior P, Johnson JA. Quality of Life After Islet Transplant: Impact of the Number of Islet Infusions and Metabolic Outcome. Transplantation 2007;84(5):664-666.
  2. Campbell PM, Senior PA, Salam A, LaBranche K, Bigam DL, Kneteman NM, Imes S, Halpin A, Ryan EA, Shapiro AMJ. High Risk of Sensitization After Failed Islet Transplantation. Am J Transplant 2007;7(10):2311-2317
  3. Lakey JRT, Kin T, Warnock GL, Shapiro AMJ, Tsapongas P, Imes S, Korbutt GS, Kneteman NM, Rajotte RV, Ryan EA. Long-Term Graft Function After Allogeneic Islet Transplantation. Cell Transplant 2007;16(4):441-446.
  4. Campbell PM, Salam A, Ryan EA, Senior P, Paty BW, Bigam D, McCready T, Halpin A, Imes S, Al Saif F, Lakey JRT, Shapiro AMJ. Pretransplant HLA Antibodies Are Associated with Reduced Graft Survival After Clinical Islet Transplantation. Am J Transplant 2007;7:1242-1248.
  5. Kin T, Rosichuk S, Shapiro AM, Lakey JR. Detection of microbial contamination during human islet isolation. Cell Transplant 2007;16(1):9-13.
  6. MWalter M, McDonald CG, Paty BW, Shapiro AMJ, Ryan EA, Senior PA. Prevalence of autoimmune diseases in islet transplant candidates with severe hypoglycaemia and glycaemic lability: previously undiagnosed celiac and autoimmune thyroid disease is identified by screening. Diabetic Medicine 2007;24:161-165.
  7. Suchak AA, O’Kelly K, Al Saif F, Shapiro AMJ, Owen RJ. Hepatic Artery-Portal Venous Fistula After Percutaneous Intraportal Islet Cell Transplant. (Letter to the Editor) Transplantation 2007;83(5):669-670.
  8. Kin T, Zhai X, Murdoch TB, Salam A, Shapiro AMJ, Lakey JRT. Enhancing the Success of Human Islet Isolation Through Optimization and Characterization of Pancreas Dissociation Enzyme. Am J Transplant 2007;7:1-8.
  9. Senior PA, Zeman M, Paty BW, Ryan EA, Shapiro AMJ. Changes in Renal Function after Clinical Islet Transplantation: Four-Year Observational Study. Am J Transplant 2007;7:91-98.
  10. SKin T, Johnson PRV, Shapiro AMJ, Lakey JRT. Factors Influencing the Collagenase Digestion Phase of Human Islet Isolation. Transplantation 2007;83:7-12.


  1. Matsumoto S, Okitsu T, Iwanaga Y, Noguchi H, Nagata H, Yonekawa Y, Liu X, Kamiya H, Ueda M, Hatanaka N, Kobayashi N, Yamada Y, Miyakawa S, Seino Y, Shapiro AMJ and Tanaka K. Follow-up Study of the First Successful Living Donor Islet Transplantation. Transplantation 2006;82(12): 1629–1633
  2. Kin T, Mirbolooki M, Salehi P, Tsukada M, O’Gorman D, Imes S, Ryan EA, Shapiro AMJ, Lakey JRT. Islet Isolation and Transplantation Outcomes of Pancreas Preserved with University of Wisconsin Solution Versus Two-Layer Method Using Peroxygenated Perfluorocarbon. Transplantation 2006;82(10:1286-1290
  3. Shapiro AMJ, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, Diercurio B, Morel P, Polonsky KS, Reems J, Bretzel RG, Bertuzzi F, Froud T, Kandaswamy R, Sutherland DER, EisenbarthG, Segal M, Preiksaitis J, Korbutt GS, Barton FB, Viviano L, Seyfert-Margolis V, Bluestone J, Lakey JRT. International Multicenter Trial of Islet Transplantation with the Edmonton Protocol in Type 1 Diabetes. New Engl J Med 2006;355(13)1318-30. Editorial by Dr. J.S. Bromberg.
  4. Berney T, Mamin A, Shapiro AMJ, Ritz-Laser B, Brulhart M-C, Toso C, Demyulder-Mischler S, Armanet M, Baertschiger R, Wojtusciszyn A, Benhamou P-Y, Bosco D, Morel P, Philippe J. Detection of Insulin mRNA in the Peripheral Blood After Human Islet Transplantation Predicts Deterioration of Metabolic Control. Am J Transplant 2006;6:1704-1711.
  5. Paty BW, Senior PA, Lakey JFRT, Shapiro AMJ, Ryan EA. Assessment of Glycemic Control After Islet Transplantation Using the Continuous Glucose Monitor in insulin-Independent Versus Insulin-Requiring Type 1 Diabetes Subjects. Diabetes Technol Ther 2006;8(2):165-172.
  6. Alsaif F, Molinari M, Al-Masloom A, Lakey JRT, Kin T, Shapiro AMJ. Pancreatic Islet Autotransplantation with Completion Pancreatectomy in the Management of Uncontrolled Pancreatic Fistula After Whipple Resection for Ampullary Adenocarcinoma (Letter to the Editor). Pancreas 2006;32(4):430-431.
  7. Mirbolooki M, Shapiro AMJ, Lakey JRT. A Perspective on Clinical Islet Transplantation: Past, Present and Developments for Future. Immun. Endoc & Metab. Agents in Med. Chem 2006;6:191-208.
  8. Salehi P, Mirbolooki M, Kin T, Tsujimura T, Shapiro AM, Churchill TA, Lakey JR. Ameliorating injury during preservation and isolation of human islets using the two-layer method with perfluorocarbon and UW solution. Cell Transplant 2006;15(2):187-94.
  9. Merani S, Shapiro AMJ. Current Status of pancreatic islet transplantation. Clin Sci 2006;110:611-625.
  10. Kin T, Murdoch TB, Shapiro AM, Lakey JR. Estimation of pancreas weight from donor variables. Cell Transplant. 2006;15(2):181-185.
  11. Shapiro AMJ. Transplanting Islets for Diabetes (Feature Article). Scientist. 2006;20(5):43.
  12. Truong W, Shapiro AMJ. Progress in Islet Transplantation in Patients with Type 1 Diabetes Mellitus. Treat Endocrinol. 2006;5(3):147-158.
  13. Ryan EA, Bigam D, Shapiro AM. Current indications for pancreas or islet transplant. Diabetes Obes Metab. 2006;8(1):1-7.
  14. Seeberger KL, Dufour JM, Shapiro AMJ, Lakey JR, Rajotte RV, Korbutt GS. Expansion of mesenchymal stem cells from human pancreatic ductal epithelium. Lab Invest. 2006;86;141-153.
  15. Nanji SA, Shapiro AM. Advances in pancreatic islet transplantation in humans. Diabetes Obes Metab. 2006; 8(1):15-25.


  1. Villiger P, Ryan E, Owen R, O’Kelly K, Oberholzer J, Al Saif F, Kin T, Wang H, Larsen I, Blitz SL, Menon V, Senior P, Bigam DL, Paty BW, Kneteman NM, Lakey JRT, Shapiro AMJ. Prevention of Bleeding After Islet Transplantation – Lessons Learned from a Multivariate Analysis of 132 Cases at a Single Institution. Am J Transpl 2005;5: 2992-2998.
  2. O’Gorman D, Kin T, Murdoch T, Richer B, McGhee-Wilson D, Ryan EA, Shapiro AMJ, Lakey JR. The Standardization of Pancreatic Donors for Islet Isolations. Transplantation2005 Sep 27;80(6):801-6.
  3. Barnett MJ, Zhai XW, Legatt DF, Cheng SB, Shapiro AMJ, Lakey JR. Quantitative Assessment of Collagenase Blends for Human Islet Isolation. Transplantation 2005; 80 (6): 723.
  4. Molinari M, Al-Saif F, Ryan EA, Lakey JRT, Senior PA, Paty BW, Bigam D, Kneteman NM, Shapiro AMJ. Sirolimus-Induced Ulceration of the Small Bowel in Islet Transplant Recipients: Report of Two Cases. Am J Transpl 2005; 5: 1-6.
  5. Senior PA, Paty BW, Cockfield SM, Ryan EA, Shapiro AMJ. Case Report: Proteinuria Developing After Clinical Islet Transplantation Resolves with Sirolimus Withdrawal and Increased Tacrolimus Dosing. Am J Transpl 2005; 5: 2318-2323.
  6. Brennan DC, Shapiro AMJ. Thrombosis and Islet Transplantation – Letter to the Editor. Transplantation 2005; 79(12): 1773.
  7. Luo B, Nanji SA, Schur CD, Pawlick RL, Anderson CC, Shapiro AMJ. Robust Tolerance to Fully Allogeneic Islet Transplants Achieved by Chimerism with Minimal Conditioning. Transplantation 2005; 80: 370-377.
  8. Ryan EA, Paty BW, Senior PA, Bigam D, Al-Fadhli E, Kneteman NM, Lakey JRT, Shapiro AMJ. Five-Year Follow-Up After Clinical Islet Transplantation. Diabetes 2005; 54:2060-2069.
  9. Emamaullee J, Liston P, Korneluk RG, Shapiro AMJ, Elliott JF. XIAP Overexpression in Islet Beta-cells Enhances Engraftment and Minimizes Hypoxia-Reperfusion Injury. Am J Transpl 2005; 5: 1297-1305.
  10. Nanji SA and Shapiro AMJ. Advances in Islet Transplantation in Humans. Diabetes, Obesity and Metabolism 2005; 8 (1), 15-25.
  11. Matsumoto S, Okitsu T, Iwanaga Y, Noguchi H, Nagata H, Yonekawa Y, Yamada Y, Fududa K, Tsukiyama K, Suzuki H, Kawasaki Y, Shimodaira M, Matsuoka K, Shibata T, Kasai Y, Maekawa T, Shapiro AMJ, Tanaka K. Insulin Independence After Living Donor Distal Pancreatectomy and Islet Allo-Transplantation. The Lancet 2005; Published on-line April 19, 2005.
  12. Senior PA, Welsh RC, McDonald CG, Paty BW, Shapiro AMJ, Ryan EA. Coronary Artery Disease is Common in Non-Uremic, Asymptomatic Type 1 Diabetic Islet Transplant Candidates. Diabetes Care 2005; 28: 866-872.
  13. Shapiro AMJ, Lakey JRT, Paty BW, Senior PA, Bigam DL, Ryan EA. Strategic Opportunities in Clinical Islet Transplantation. Transplantation 2005; 79(10); 1304-1307.
  14. Ryan EA, Paty BW, Senior PA, Lakey JRT, Bigam D, Al-Fadhli E, Shapiro AMJ. b-Score: An Assessment of Beta-Cell Function After Islet Transplantation. Diabetes Care 2005; 28: 343-347.
  15. Shapiro AMJ, Gallant HL, Hao EG, Lakey JRT, McCready T, Rajotte RV, Yatscoff RW, Kneteman NM. The Portal Immunosuppressive Storm – Relevance to Islet Transplantation? Ther Drug Mon 2005; 27(1); 35-37.


  1. Shapiro AMJ, Ricordi C. Unraveling the Secrets of Single Donor success in Islet Transplantation. Am J Transpl 2004; 4: 295-8.
  2. Johnson JA, Kotovych M, Ryan EA, Shapiro AMJ. Reduced Fear of Hypoglycemia in Successful Islet Transplantation. Diabetes Care 2004; 27(2): 624-5.
  3. Tsujimura T, Kuroda Y, Churchill TA, Avila JG, Kin T, Shapiro AMJ, Lakey JRT. Short-Term Storage of the Ischemically Damaged Human Pancreas by the Two-Layer Method Prior to Islet Isolation. Cell Transplantation 2004; 13:67-73.
  4. Ryan EA, Shandro T, Green K, Paty BW, Bigam D, Shapiro AMJ, Vantyghem MC. Assessment of the Severity of Hypoglycemia and Glycemic Lability in Type 1 Diabetic Subjects Undergoing Islet Transplantation. Diabetes 2004; 53:955-962.
  5. Rose NL, Palcic MM, Shapiro AMJ, Lakey JRT. Endogenous Pancreatic Enzyme Activity levels Show No Significant Effect on Human Islet Isolation Yield. Cell Transplantation 2004; 13:153-160.
  6. Paty BW, Bonner-Weir S, Laughlin M, McEwan AJ, Shapiro AMJ. Towards Development Of Imaging Modalities For Islets After Transplantation: Insights From The National Institutes Of Health Workshop On Beta Cell Imaging. Transplantation 2004; 77(8):1133-1137.
  7. Street CN, Lakey JRT, Seeberger K, Helms L, Rajotte RV, Shapiro AMJ, Korbutt GS. Heterogenous Expression of Nestin in Human Pancreatic Tissue Precludes Its Use As An Islet Precursor Marker. J Endocrinology 2004; 180: 213-225.
  8. Bhargava R, Senior PA, Ackerman TE, Ryan EA, Paty BW, Lakey JRT, Shapiro AMJ. Prevalence of Hepatic Steatosis After Islet Transplantation and Its Relationship to Graft Function. Diabetes 2004; 53:1311-1317.
  9. Tsujimura T, Kuroda Y, Avila JG, Kin T, Oberholzer J, Shapiro AMJ, Lakey JRT. Influence of Pancreas Preservation on Human Islet Isolation Outcomes: Impact of the Two-Layer Method. Transplantation 2004; 78(1): 96-100.
  10. Brennan DC, Desai N, Shannon MB, Robertson H, O’Brien L, Polonsky KS, Shapiro AMJ. Portal Vein Thrombosis Complicating Islet Transplantation in a Recipient with the Factor V Leiden Mutation. Transplantation 2004; 78(1): 172-173.
  11. Street CN, Lakey JRT, Rajotte RV, Shapiro AMJ, Kieffer TJ, Lyon JG, Kin T, Korbutt GS. Enriched Human Pancreatic Ductal Cultures Obtained from Selective Death of Acinar Cells Express Pancreatic and Duodenal Homeobox Gene-1 Age-Dependently. Rev Diab Stud 2004; 1:66-79.
  12. Senior PA, Shapiro AMJ, Ackerman TE, Ryan EA, Paty BW, Bhargava R. Magnetic Resonance-Defined Perinephric Edema After Clinical Islet Transplantation: A Benign Finding Associated With Mild Renal Impairment. Transplantation 2004; 78(6): 945-948.
  13. McDonald CG, Ryan EA, Paty BW, Senior PA, Marshall SM, Lakey JRT, Shapiro AMJ. Cross-Sectional and Prospective Association Between Proinsulin Secretion and Graft Function After Clinical Islet Transplantation. Transplantation 2004; 78(6): 934-937.
  14. Ryan EA, Paty BW, Senior PA, Shapiro AMJ. Risks and Side Effects of Islet Transplantation. Curr Diab Rep 2004; 4:304-309.
  15. Nanji SA, Shapiro AMJ. Islet Transplantation in Patients with Diabetes Mellitus: Choice of Immunosuppression. BioDrugs 2004; 18(5):315-328.
  16. Burridge PW, Shapiro AMJ, Ryan EA, Lakey JRT. Clinical Islet Transplantation in The New Millennium. J of the Egypt Soc Endocrin Metab and Diab 2004; 35(1&2):5-10.
  17. Barnett MJ, McGhee-Wilson D, Shapiro AMJ, Lakey JRT. Variation in Human Islet Viability Based on Different Membrane Integrity Stains. Cell Transplantation 2004; 13: 481-488.
  18. Street CN, Lakey JRT, Shapiro AMJ, Imes S, Rajotte RV, Ryan EA, Lyon JG, Kin T, Avila J, Tsujimura T, Korbutt GS. Islet Graft Assessment in the Edmonton Protocol: Implications for predicting long term clinical outcome. Diabetes 2004; 43: 3107-3114.
  19. Bigam DL, Shapiro AMJ. Pancreatic Transplantation. Curr Treatment Options in Gastroenterol 2004; 7(5):329-341.


  1. Orive G, Hernandez RM, Gascon AR, Calafiore R, Chang TMS, De Vos P, Hortelano G, Hunkeler D, Lacik I, Shapiro AMJ, Pedraz JL. Cell Encapsulation: Promise and Progress. Nature Medicine 2003; 9(1):104-107.
  2. Shapiro AMJ, Lakey JRT. Islet Transplant – A Secure Future for Cellular Replacement Therapy in Diabetes. Pract Diab Intl 2003; 20(4):1-5.
  3. Hathout E, Lakey JRT, Shapiro AMJ. Islet Transplant: An Option for Childhood Diabetes? Arch Dis Child 2003; 88(7):591-594.
  4. Shapiro AMJ. Islet Transplants and Impact on Secondary Diabetic Complications: Does C-Peptide Protect the Kidney? J Am Soc Nephrol 2003; 14:2214-2216.
  5. Lakey JRT, Burridge PW, Shapiro AMJ. Technical Aspects of Islet Preparation and Transplantation. Transpl Int 2003; 16(9):613-632.
  6. Oberholzer J, Shapiro AMJ, Lakey JR, Ryan EA, Rajotte RV, Korbutt GS, Morel P, Kneteman NM. Current Status of Islet Cell Transplantation. Adv Surg 2003; 37:253-282.
  7. Owen RJT, Ryan EA, O’Kelly K, Lakey FRT, McCarthy M, Paty BW, Bigam D, Kneteman NM, Korbutt GS, Rajotte RV, Shapiro AMJ. Percutaneous Transhepatic Pancreatic Islet Cell Transplantation in Type I Diabetes: Radiological Aspects. Radiology 2003; 229(1).
  8. Shapiro AMJ, Hering BJ, Ricordi C. Edmonton’s Success Has Indeed Been Replicated Elsewhere. The Lancet 2003; 362:1242.
  9. Toso C, Morel P, Bucher P, Shapiro AMJ, Mathe Z, Demuylder S, Bosco D, Berney T, Philippe J and Oberholzer J. Insulin-independence after Conversion to Tacrolimus and Sirolimus Based Immunosuppression in Islet-Kidney Recipients. Transplantation 2003; 76(7): 1133-1134.
  10. Rose NL, Palcic MM, Shapiro AMJ, Lakey JRT. An Evaluation of the Activation of Endogenous Pancreatic Enzymes During Human Islet Isolations. Transplantation Proceedings 2003; 35: 2455-7.
  11. Rose NL, Palcic MM, Shapiro AMJ, Lakey JRT. An Evaluation of Endogenous Pancreatic Enzyme Levels Following Enzymatic Digestion. Transplantation Proceedings 2003; 35:2458-60.
  12. Tsujimura T, Kuroda Y, Avila JG, Kin T, Churchill TA, Shapiro AMJ, Lakey JRT. Resuscitation of the Ischemically Damaged Human Pancreas by the Two-Layer Method Prior to Islet Isolation. Transplantation Proceedings 2003; 35: 2461-2.
  13. Shapiro AMJ, Nanji SA, Lakey JRT. Clinical Islet Transplant – Current and Future Directions Towards Tolerance. Immunological Reviews 2003; 196: 219-36.
  14. Rafael E, Ryan EA, Senior P, McDonald C, Paty BW, Imes S, Shapiro AMJ, Olberholzer J, Lakey JRT. Changes in Liver Enzymes After Clinical Islet Transplantation. Transplantation 2003; 76: 1280-4.


  1. Shapiro AMJ, Suarez-Pinzon WL, Power R and Rabinovitch A. Combination Therapy with Low Dose Sirolimus and Tacrolimus is Synergistic in Preventing Spontaneous and Recurrent Autoimmune Diabetes in Non-Obese Diabetic Mice. Diabetologia 2002; 45:224-230.
  2. Rabinovich A, Suarez-Pinzon WL, Shapiro AMJ, Rajotte RV and Power R. Combination Therapy with Sirolimus and Interleukin-2 Induces Long-Term Prevention of Spontaneous and Recurrent Autoimmune Diabetes in NOD Mice. Diabetes 2002; 51:638-645.
  3. Lakey JRT, Tsujimura T, Shapiro AMJ and Kuroda Y. Human Pancreas Preservation Prior to Islet Isolation. Cell Preservation Technology 2002; 1(1): 81-87.
  4. Lakey JR, Kneteman NM, Rajotte RV, Wu DC, Bigam D and Shapiro AMJ. Effect of core pancreas temperature during cadaveric procurement on human islet isolation and functional viability. Transplantation 2002; 73(7): 1106-10.
  5. Ryan EA, Lakey JRT, Paty BW, Imes S, Korbutt GS, Kneteman NM, Bigam D, Rajotte RV and Shapiro AMJ. Successful Islet Transplantation: Continued Insulin Reserve Provides Long-Term Glycemic Control. Diabetes 2002; 51(7): 2148-57.
  6. Casey JJ, Lakey JRT, Ryan EA, Paty BW, Owen R, O’Kelly K, Nanji S, Rajotte RV, Korbutt GS, Bigam D, Kneteman NN and Shapiro AMJ. Portal Venous Pressure Changes following Sequential Clinical Islet Transplantation. Transplantation 2002; 74(7): 913-915.
  7. Shapiro AMJ , Ryan E, Rajotte R, Korbutt G, Kneteman N, Bigam D, Paty, B, Lakey JRT. Improved Function of Islet Grafts Under Steroid-Free Immunosuppression: Will Grafts Work Forever? Transplantation 2002; 73(9): 1528.
  8. Burridge PW, Shapiro AMJ, Ryan EA, Lakey JRT. Future Trends in Clinical Islet Transplantation. Transplantation Proceedings 2002; 34(8):3347-8.
  9. Paty BW, Ryan EA, Shapiro AMJ, Lakey JRT and Robertson RP. Intrahepatic Islet Transplantation in Type 1 Diabetic Patients Does Not Restore Hypoglycemic Hormonal Counterregulation or Symptom Recognition After Insulin Independence. Diabetes 2002; 51:3428-34.
  10. Shapiro AMJ . Eighty Years After Insulin: Parallels with Modern Islet Transplantation. CMAJ 2002; 167(12):1398-1400.
  11. Tsujimura, T, Kuroda Y, Kin T, Avila JG, Rajotte RV, Korbutt GS, Ryan EA, Shapiro AMJ, Lakey FRT. Human Islet Transplantation from Pancreases with Prolonged Cold Ischemia Using Additional Preservation by the Two-Layer (UW Solution/Perfluorochemical) Cold Storage Method. Transplantation 2002; 74(12):1687-91.


  1. Shapiro AMJ, Ryan EA and Lakey JRT. Islet Cell Transplantation. The Lancet Suppl 2001; 358: S21
  2. Shapiro AMJ, Ryan E, Warnock G, Kneteman NM, Lakey J, Korbutt GS and Rajotte RV. Could fewer islet cells be transplanted in type 1 diabetes? Insulin independence should be the dominant force in islet transplantation. BMJ 2001; 322:861
  3. Lakey JRT, Helms LMH, Kin T, Korbutt GS, Rajotte RV, Shapiro AMJ and Warnock GL. Serine-Protease Inhibition During Islet Isolation Increases Islet Yield from Human Pancreases with Prolonged Ischemia. Transplantation 2001; 72 (4): 565.
  4. Ryan EA, Lakey JRT, Rajotte RV, Korbutt GS, Kin T, Imes S, Rabinovitch A, Elliott JF, Bigam D, Kneteman NM, Warnock GL, Larsen I and Shapiro AMJ. Clinical Outcomes and Insulin Secretion After Islet Transplantation with the Edmonton Protocol. Diabetes 2001; 50:710-719.
  5. Ryan EA, Lakey JR, Shapiro AMJ. Clinical Results After Islet Transplantation. J Investig Med 2001; 49(6):559-562.


  1. Shapiro AMJ, Lakey JRT, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM and Rajotte RV. Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen. N Engl J Med 2000; 343(4): 230-8.

For more information contact the Clinical Islet Transplant Program in Edmonton:

Clinical Islet Transplant Program
2000 College Plaza
8215-112th Street Edmonton, Alberta, Canada T6G 2C8
Email: isletprogram@islet.ca