Key Scientific Publications

  1. Shapiro AMJ, Lakey JRT, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM and Rajotte RV. Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen.N Engl J Med 2000; 343(4): 230-8.PubMed
  2. Ryan EA, Lakey JRT, Rajotte RV, Korbutt GS, Kin T, Imes S, Rabinovitch A, Elliott JF, Bigam D, Kneteman NM, Warnock GL, Larsen I and Shapiro AMJ. Clinical Outcomes and Insulin Secretion After Islet Transplantation with the Edmonton Protocol. Diabetes 2001; 50:710-719.PubMed
  3. Ryan EA, Lakey JRT, Paty BW, Imes S, Korbutt GS, Kneteman NM, Bigam D, Rajotte RV and Shapiro AMJ. Successful Islet Transplantation: Continued Insulin Reserve Provides Long-Term Glycemic Control.Diabetes 2002; 51(7): 2148-57. PubMed
  4. Ryan EA, Paty BW, Senior PA, Shapiro AMJ. Risks and Side Effects of Islet Transplantation.Curr Diab Rep 2004; 4:304-309.PubMed
  5. Ryan EA, Shandro T, Green K, Paty BW, Bigam D, Shapiro AMJ, Vantyghem MC. Assessment of the Severity of Hypoglycemia and Glycemic Lability in Type 1 Diabetic Subjects Undergoing Islet Transplantation.Diabetes 2004; 53:955-962.PubMed
  6. Ryan EA, Paty BW, Senior PA, Lakey JRT, Bigam D, Al-Fadhli E, Shapiro AMJ.Beta-Score: An Assessment of Beta-Cell Function After Islet Transplantation.Diabetes Care 2005; 28: 343-347.PubMed
  7. Ryan EA, Paty BW, Senior PA, Bigam D, Al-Fadhli E, Kneteman NM, Lakey JRT, Shapiro AMJ. Five-Year Follow-Up After Clinical Islet Transplantation. Diabetes 2005; 54:2060-2069. PubMed
  8. Paty BW, Senior PA, Lakey JFRT, Shapiro AMJ, Ryan EA. Assessment of Glycemic Control After Islet Transplantation Using the Continuous Glucose Monitor in insulin-Independent Versus Insulin-Requiring Type 1 Diabetes Subjects. Diabetes Technol Ther 2006;8(2):165-172. PubMed
  9. Senior PA, Zeman M, Paty BW, Ryan EA, Shapiro AM. Changes in Renal Function after Clinical Islet Transplantation: Four-year Observational Study. Am J Transplant 2007;7(1):91-8. PubMed