Thank you for visiting the Clinical Islet Transplant Program website! We hope you will find this site useful.
The landmark NIH Registration Trial of Clinical Islet Transplantation has just been published. This shows that islet transplantation provides robust protection from severe hypoglycemia and excellent glycemic control over 2 years.
We have published outcomes from our program over the last 20 years - showing long term protection from hypoglycemia, lower A1c and insulin requirements in those with sustained graft function
A study of quality of life after islet transplantation from the patient's point of view has been published which gives a different perspective than we usually hear.
We've recently developed a tool (the BETA-2 score) which allows us to calculate a score to measure the function of an islet transplant from a single fasting blood test. This will allow us to monitor function more easily and more frequently over time. There is even an online tool to calculate the score.
The HYPO score is a tool used to assess the frequency and severity of hypoglycaemia. We've got a tool to help automate its calculation.
If you wish to register your interest to volunteer for one of our current or future research studies, please click here.
New Onset Type 1 Diabetes - recruiting NOW
We are recruiting people who have developed Type 1 Diabetes in the last 6 months to receive treatments which aim to reset the immune system and mobilize stem cells - hoping that will reverse or prevent further immune attack of pancreatic beta cells. Specific information for this trial can be found here.
Viacyte's VC-01 & VC-02 Beta-Cell Replacement...
Viacyte have developed a line of pancreatic endoderm cells (PEC-01). We are looking for volunteers with Type 1 Diabetes to help us move forward in our efforts to bring "stem cell therapy" to the clinic. The VC-01 Trial is currently underway but not recruiting patients. The VC-02 Trial, however, is underway and actively recruiting. Specific information for the VC-02 trial can be found here.
Polyclonal Regulatory T cell (PolyTreg) Immunotherapy in Islet Transplantation - recruiting NOW
Polyclonal Regulatory T cells (PolyTregs) are a sub-set of specialized regulatory cells that have demonstrated immune protection of transplant grafts in pre-clinical models, and may hold great promise in clinical islet transplantation. PolyTRegs are harvested and expanded from a recipient's whole blood prior to islet transplantation and infused several weeks after the islet transplant procedure. The anticipation is that the infused PolyTregs will protect the islet graft from the recipient's immune response and the patient will require less immune suppression drugs over the lifetime of the graft. For more information about the PolyTreg trial, please contact one of our study coordinators: email@example.com or firstname.lastname@example.org.
AT-1501 Immunomodulation in Islet Transplant
"Regular" Clinical Islet Transplants
Too much information to read? Watch some video clips which describe islet transplantation!
A summary of progress in the Islet Transplant Program has been published in the Canadian Journal of Diabetes.
Shortage of Applicants
Currently our wait list is very short, partly because we have successfully transplanted many people who formerly had Type 1 diabetes. In addition many people have been reluctant to apply, often because they think that islet transplant is for "other people". Our islet transplant recipients are normal people, just like you. More info...
We are actively processing applications...
... so if you think that an islet transplant might be right for you, please apply
Information for Canadian Residents
Detailed patient information is provided on this site. Please see the links on the left hand side.
We have an information pack which you may like to download and print
If you are not sure if you might be a candidate you may want to start here
The following individuals are closely involved with the Clinical Islet Transplant Program in Edmonton:
Dr. James Shapiro (Director / Transplant Surgeon)
Dr. Peter Senior (Medical Director/Endocrinologist)
Dr Anna Lam (Endocrinologist)
Dr. David Bigam (Transplant Surgeon)
Dr. Khaled Dajani (Transplant Surgeon)
Dr. Blaire Anderson (Transplant Surgeon)
And many others: interventional radiology doctors and staff, nurse coordinators, islet isolation staff, dietitian, patient and family support coordinator, metabolic coordinator, research staff, and clerical staff.
Information for International Residents
US and international inquiries regarding islet transplant programs outside of Canada should be directed to:
For more information contact the Clinical Islet Transplant Program in Edmonton:
Clinical Islet Transplant Program
2-132 Li Ka Shing Centre for Health Research Innovation
Edmonton, Alberta, Canada T6G 2E1
Copyright 2010 Clinical Islet Transplant Program